A REVIEW ON THE RELEVANCE OF MOLECULAR KARYOTYPING IN AML
Sundar Raj M, S.Krishna Priya
International Research Journal in Global Engineering and Sciences (IRJGES), 2017, Vol.3. Issue 3. pp. 1-8
Abstract: Acute myeloid leukemia (AML) is an aggressive disorder characterized via the overproduction of immature myeloid cells that accumulate in blood and bone marrow. Integration of genetic findings and clinicopathological facts is critical in establishing the diagnosis, prognosis and identifying the therapeutic approach in the administration of AML patients. In current years, the AML classification has developed from morphology to cytogenetics/molecular genetics-based findings, which is indispensable in the detection of chromosomal abnormalities and has provided the framework for the analysis and riskstratification in AML. Moreover, with advances in molecular karyotyping such as comparative genomic hybridization (CGH) and single nucleotide polymorphism (SNP) arrays, a number of obstacles of traditional diagnostic techniques have been overcome. Hence, this review focuses on the insights into molecular karyotyping using CGH and SNP arrays which allow the identification of replica wide variety versions (CNVs) at a higher resolution and facilitate the detection of replica impartial loss of heterozygosity (CN-LOH) otherwise undetectable by using traditional cytogenetics. Technical hindrances of these strategies (e.g. regions of losses, gains, or â€œundulating wavesâ€) are also mentioned in the context of AML.
Keywords: Copy Number Variants, Genomic Analysis, Microarray, Acute Myeloid Leukemia, Comparative Genomic Hybridization
S.V.Saji Rekha, D.Beula Shiny "A Review on the Relevance of Molecular Karyotyping in AML" , International Research Journal in Global Engineering and Sciences (IRJGES), 2018, Vol.3. Issue 3. pp. 1-8